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Activating Curcumin


Nearly each curcumin examine I reviewed (22/26 medical research) discovered anti-inflammatory results following train; each related examine (12/12) discovered results resulting in sooner restoration. Inspecting that analysis affords some clarification as to why.

A standard factor is that curcumin impacts sure immune system biomarkers – like signaling proteins (cytokines) and mRNA – which are accountable for initiating inflammatory actions. The method is in fact extra sophisticated than can simply be summarized right here, however these biomarkers function the immune system’s first responders, rolling up into broken areas to wash up the catastrophe space to arrange for the restore course of. On the outset, this course of causes the irritation and delayed onset muscle soreness that we’re all conversant in.

In very brief, easy phrases, curcumin’s impact on these biomarkers balances towards over-inflammation brought on by the acute stress of endurance coaching, accelerating tissue restoration in relation to emphasize and harm brought on by endurance train and shortening durations of exercise-induced soreness and irritation. It has an analogous impact on long-term ache and discomfort, particularly in connective tissues that don’t get better and restore as quick as muscle and bone and are due to this fact extra weak to continual points related to overtraining.


Train-induced irritation is helpful, however it might probably create points whether it is allowed to run rampant. This can be a main concern throughout long-term train, when your connective tissues are below fixed mechanical and bodily stress with a corresponding fixed inflammatory response. Persistent accidents, lingering discomfort, lack of operate – all signs of overtraining that may be brought on by imbalanced irritation maintaining connective tissues in an emergency response state with out transitioning effectively right into a rebuild and restore state.

For endurance athletes, balancing your physique’s inflammatory response to train means extra safety towards overtraining, sooner restoration from soreness, and fewer continual joint and connective tissue ache. Curcumin does present different advantages – together with immune help, liver well being, psychological acuity, and blood circulation – however the anti-inflammatory advantages for connective tissues are crucial for endurance athletes. They’re additionally typically ignored by complement and vitamin methods, making HALO a novel answer to one in all endurance coaching’s most typical issues: lingering, debilitating connective tissue discomfort.


All through a lot of this weblog, I’ve been targeted on connective tissues. That’s as a result of they’re advanced for simplicity with the intention to cut back the danger of one thing going improper, however that evolution additionally slows their capability to restore and adapt in comparison with tissues like muscle and bone. They’re weak to the stresses of endurance coaching, however they’re additionally crucial to sustaining efficiency over lengthy durations.

We consider joints as places, like knee or ankle; nonetheless, when they’re sore from overexertion, there are a number of connective tissues concerned, together with tendons, ligaments, cartilage, synovial (joint) linings, bursa, periosteum, and bone. And every muscle has connective tissues inside itself – basal lamina, epimysium, endomysium, sheaths – that form and maintain your muscle tissue, nerves, and blood vessels in working order. Immune system cells, blood vessels, and nerves are all the time hanging in and round connective tissues, too.

Although they sound sophisticated and overbuilt, connective tissues have really advanced to face up to stress by trending in direction of simplicity, omitting sure buildings which may be extra weak to wreck and due to this fact compromise mobility. Not like muscle tissue, connective tissues in joints are locked into their form and have fewer cells. Some are additionally inside articular joints, the place there are not any blood or lymphatic vessels.

These omissions imply connective tissues have a tougher time recovering from exercise-induced microdamage. They do have strong upkeep and restore processes consistently ongoing, however at a a lot slower price than different bodily buildings – they’ll take twice as lengthy to normalize (or heal) in comparison with bones, for instance, and that interval is even longer if structural harm is fixed, as in overuse accidents widespread in endurance athletes.

Given all of those elements, connective tissues and joints are unsurprisingly adversely affected by the delayed onset soreness and exercise-induced irritation of endurance coaching. Extended durations of overbearing irritation hit connective tissues tougher than different tissues as a result of they take longer to maneuver past the emergency response part of irritation to the rebuilding and restoration part that follows. Finally, you’re looking at continual overuse accidents and nagging connective tissue ache.


Lastly, I need to embody a observe about curcumin vs. curcuminoids and clarify why we supply the curcuminoids that we do. Many corporations are doing curcumin, however research-driven sourcing and ratios are a fundamental cause why First Endurance is doing curcumin proper.

HALO’s curcumin content material is definitely three intently associated polyphenols: curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC). All three of those curcuminoids happen naturally in turmeric (Curcuma longa) roots and rhizomes, they usually represent about 2-5% of turmeric root powder. For HALO, we use an ethanol-water extract of turmeric roots to spice up that quantity to 95%.

Turmeric curcuminoids are sometimes 60-70% curcumin, with lesser quantities of DMC (20-27%) and BDMC (10-15%). Thus, 1,000mg of the 95% extract in HALO contains 570-665mg of curcumin, 190-257mg of DMC, and 95-143mg of BDMC.

Each DMC and BDMC present equal or larger actions as curcumin, so blended curcuminoids are greater than akin to 95% or 100% curcumin (with out the opposite two compounds) for organic actions. Due to that, we choose to make use of the pure types and ratios of curcuminoids as present in turmeric root somewhat than isolate curcumin by itself, which is extra widespread amongst different dietary supplements. With all three curcuminoids, the pure kind merely has the next ceiling of effectiveness, which much less us really use much less whereas nonetheless enhancing the measurable advantages. We went with how human our bodies work, not learn how to drive extra compounds into the physique towards how our our bodies work.



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